The research areas associated with the biophysical, structural, functional, and evolutionary characterization of different proteins are conducted by the Laboratory of Protein Biophysics, Biochemistry, and Bioinformatics (PB³), which bridges the interaction between CEBEM and IIBM UC.

PB³ is led by César A. Ramírez-Sarmiento, Associate Professor at IIBM UC. PB³ employs experimental and computational strategies to unveil the folding, function, and evolution relationships of many proteins of biomedical and biotechnological interest.

Currently, their research focuses on the characterization of metamorphic proteins that undergo dramatic changes in their secondary and tertiary structure to regulate gene expression in bacteria, the characterization and engineering of enzymes that hydrolyze PET plastic, the development of open molecular kits for viral infection detection, and the engineering of photosynthetic organisms as oxygen carriers for tissue oxygenation in animals.